Activating Compound | Comment | Organism | Structure |
---|---|---|---|
haloperidol | chronic treatment with 20 mg/kg clozapine increases PDE4B2 and PDE4B4 expression by 102 and 71%, respectively | Rattus norvegicus | |
additional information | PDE4B1, PDE4B2, PDE4B3, and PDE4B4 are not changed by chronic haloperidol treatment | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expressed in COS-1 cells | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
membrane | - |
Rattus norvegicus | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
58000 | - |
PDE4B4 recombinant protein, SDS-PAGE | Rattus norvegicus |
69000 | - |
PDE4B2 recombinant protein, SDS-PAGE | Rattus norvegicus |
87000 | - |
PDE4B1 or PDE4B3 recombinant protein, SDS-PAGE, the 87000 Da band is termed PDE4B1/B3 due to difficulty of resolving it into separate bands using SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
corpus striatum | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | - |
Rattus norvegicus | 5'-AMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE4B | - |
Rattus norvegicus |
PDE4B1 | isozyme | Rattus norvegicus |
PDE4B2 | isozyme | Rattus norvegicus |
PDE4B3 | isozyme | Rattus norvegicus |
PDE4B4 | isozyme | Rattus norvegicus |
phosphodiesterase-4B | - |
Rattus norvegicus |